I read a reasonable amount of comics in TPB or Graphic Novel format. Usually, these are easy and quick reads, perfect for long days when I am sitting in bed getting sleepy. I like to think I am pretty discerning when it comes to comics -- I'm an adult and want good plots supported by interesting characters. So, with that said, I wholeheartedly suggest...
Locke and Key:
Its really, really good. The art is amazing and the plot is genuinely creepy and suspenseful. Its the story of a family, ripped apart by tragedy, and beset by all sorts of (inter-related) supernatural events. This is very much an adult comic with blood, violence and adult themes laced throughout the panels.
Whats really nice about Locke and Key is the art nicely supports the complex story-telling. If havent seen attention to detail in the art like this since the old Image series The Maxx. Many panels have little hints and foreshadowing buried in the crisp art, encouraging you to linger on each panel for a couple seconds to make sure you catch everything. Good stuff...
My other hotness lately is Powers:
Powers is not new (there are, like, 13 collections out already -- with more to come), and a lot of great reviews already exist (so i am not the only one crowing about its quality). Its a little like the Wire meets Heroes. Powers is the, hands-down, best super heroes comic I have ever read. Its also the best crime drama/noir comic I have ever read. Funny how it can be both... but thats what good writing will get 'ya. Again, adult situations and themes carry these books, so they are not for the wee ones.
There you go. Go buy 'em!